Informasjon

Polycystisk ovariesyndrom (PCOS)

Polycystisk ovariesyndrom (PCOS) er en tilstand som kjennetegnes av symptomer som økt nivå av mannlige kjønnshormoner, mange små blærer (cyster) på eggstokkene og sjeldne og/eller uregelmessige menstruasjoner.

PregMet2-studien

Pågående studie (2016) som undersøker om metformin kan forbygge sene aborter og fortidlige fødsler hos gravide kvinner med PCOS.

Her kan du lese om studien og eventuelt melde deg på.

Vil du vite mer?

Få tilgang på artikkelen om dette temaet fra Legehandboka.no

Artikkelen inneholder all informasjon norske allmennleger bruker i sitt daglige arbeid.

Jeg har lest og akseptert Brukervilkår ved kjøp av NEL-dokumenter

Dette dokumentet er basert på det profesjonelle dokumentet "Polycystisk ovariesyndrom". Referanselisten for dette dokumentet vises nedenfor.

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41-7. pmid: 14688154 PubMed
Williams T, Mortada R, Porter S. Diagnosis and treatment of polycystic ovary syndrome. Am Fam Physician 2016; 94: 106-13. pmid: 27419327 PubMed
Dewailly D, Lujan ME, Carmina E, et al. Definition and significance of polycystic ovarian morphology: a task force report from the Androgen Excess and Polycystic Ovary Syndrome Society. Hum Reprod Update. May-Jun 2014;20(3):334-352. pmid: 24345633 PubMed
Taponen S, Martikainen H, Jarvelin MR, et al. Hormonal profile of women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland birth cohort 1966 study. J.Clin.Endocrinol.Metab. 2003;88(1):141-47. pmid: 12519843 PubMed
March WA, Moore VM, Willson KJ, Phillips DI, Norman RJ, Davies MJ. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum.Reprod. 2010;25(2):544-551. pmid: 19910321 PubMed
Eilertsen TB, Vanky E, Carlsen SM. Increased prevalence of diabetes and polycystic ovary syndrome in women with a history of preterm birth: a case-control study. BJOG. 2012;119(3):266-275. pmid: 22168920 PubMed
Tehrani FR, Simbar M, Tohidi M, Hosseinpanah F, Azizi F. The prevalence of polycystic ovary syndrome in a community sample of Iranian population: Iranian PCOS prevalence study. Reprod Biol Endocrinol. 2011;9:39. pmid: 21435276 PubMed
Randeva HS, Tan BK, Weickert MO, et al. Cardiometabolic aspects of the polycystic ovary syndrome. Endocr Rev. Oct 2012;33(5):812-841. PubMed
Hutchison SK, Stepto NK, Harrison CL, Moran LJ, Strauss BJ, Teede HJ. Effects of exercise on insulin resistance and body composition in overweight and obese women with and without polycystic ovary syndrome. J Clin Endocrinol Metab. Jan 2011;96(1):E48-56. PubMed
Moran LJ, Hutchison SK, Norman RJ, Teede HJ. Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2011(7):CD007506. Cochrane (DOI)
Moran LJ, Noakes M, Clifton PM, Tomlinson L, Galletly C, Norman RJ. Dietary composition in restoring reproductive and metabolic physiology in overweight women with polycystic ovary syndrome. J Clin Endocrinol Metab. Feb 2003;88(2):812-819. PubMed
Joham AE, Ranasinha S, Zoungas S, Moran L, Teede HJ. Gestational diabetes and type 2 diabetes in reproductive-aged women with polycystic ovary syndrome. J Clin Endocrinol Metab. Mar 2014;99(3):E447-452. PubMed
Moran LJ, Misso ML, Wild RA, Norman RJ. Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. Jul-Aug 2010;16(4):347-363.
Legro RS. Obesity and PCOS: implications for diagnosis and treatment. Semin Reprod Med. Dec 2012;30(6):496-506. pmid: 23074008 PubMed
Pinola P, Piltonen TT, Puurunen J, et al. Androgen Profile Through Life in Women With Polycystic Ovary Syndrome: A Nordic Multicenter Collaboration Study. J Clin Endocrinol Metab. Sep 2015;100(9):3400-3407. PubMed
Dumesic DA, Lobo RA. Cancer risk and PCOS. Steroids. Aug 2013;78(8):782-785. PubMed
Kahsar-Miller MD, Nixon C, Boots LR, Go RC, Azziz R. Prevalence of polycystic ovary syndrome (PCOS) in first-degree relatives of patients with PCOS. Fertil Steril. Jan 2001;75(1):53-58. PubMed
Torvinen A, Koivunen R, Pouta A, et al. Metabolic and reproductive characteristics of first-degree relatives of women with self-reported oligo-amenorrhoea and hirsutism. Gynecol Endocrinol. Sep 2011;27(9):630-635. PubMed
McCartney CR, Prendergast KA, Chhabra S, et al. The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. J Clin Endocrinol Metab. May 2006;91(5):1714-1722. PubMed
Mansson M, Holte J, Landin-Wilhelmsen K, Dahlgren E, Johansson A, Landen M. Women with polycystic ovary syndrome are often depressed or anxious--a case control study. Psychoneuroendocrinology. Sep 2008;33(8):1132-1138. PubMed
Scaruffi E, Gambineri A, Cattaneo S, Turra J, Vettor R, Mioni R. Personality and psychiatric disorders in women affected by polycystic ovary syndrome. Front Endocrinol (Lausanne). 2014;5:185. PubMed
Kristensen SL, Ramlau-Hansen CH, Ernst E, et al. A very large proportion of young Danish women have polycystic ovaries: is a revision of the Rotterdam criteria needed? Hum Reprod. Dec 2010;25(12):3117-3122. PubMed
Gambineri A, Patton L, Altieri P, et al. Polycystic ovary syndrome is a risk factor for type 2 diabetes: results from a long-term prospective study. Diabetes. Sep 2012;61(9):2369-2374. PubMed
Moran LJ, Pasquali R, Teede HJ, Hoeger KM, Norman RJ. Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society. Fertil Steril. Dec 2009;92(6):1966-1982. PubMed
Tang T, Lord JM, Norman RJ, Yasmin E, Balen AH. Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane.Database.Syst.Rev. 2009 2009(4):CD003053. Cochrane (DOI)
Legro RS, Barnhart HX, Schlaff WD, et al. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med. 2007;356(6):551-566. pmid: 17287476 PubMed
Kjotrod SB, Carlsen SM, Rasmussen PE, et al. Use of metformin before and during assisted reproductive technology in non-obese young infertile women with polycystic ovary syndrome: a prospective, randomized, double-blind, multi-centre study. Hum Reprod. 2011;26(8):2045-53. pmid: 21606131 PubMed
Morin-Papunen L, Rantala AS, Unkila-Kallio L, et al. Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial. J Clin Endocrinol Metab. May 2012;97(5):1492-1500. PubMed
Vanky E, Zahlsen K, Spigset O, Carlsen SM. Placental passage of metformin in women with polycystic ovary syndrome. Fertil Steril. 2005;83(5):1575-78. pmid: 15866611 PubMed
Cassina M, Dona M, Di Gianantonio E, Litta P, Clementi M. First-trimester exposure to metformin and risk of birth defects: a systematic review and meta-analysis. Hum Reprod Update. 2014;20(5):656-69. pmid: 24861556 PubMed
Franik S, Eltrop SM, Kremer JA, et al. Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2018 May 24;5:CD010287. doi: 10.1002/14651858.CD010287.pub3 DOI
Nahuis MJ, Kose N, Bayram N, et al. Long-term outcomes in women with polycystic ovary syndrome initially randomized to receive laparoscopic electrocautery of the ovaries or ovulation induction with gonadotrophins. Hum Reprod. Jul 2011;26(7):1899-1904. PubMed
Koivunen R, Pouta A, Franks S, et al. Fecundability and spontaneous abortions in women with self-reported oligo-amenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study. Hum Reprod. Sep 2008;23(9):2134-2139. PubMed
Vanky E, Stridsklev S, Heimstad R, et al. Metformin Versus Placebo from First Trimester to Delivery in Polycystic Ovary Syndrome: A Randomized, Controlled Multicenter Study. J Clin Endocrinol Metab. 2010;95(12):E448-55. pmid: 20926533 PubMed
Kjerulff LE, Sanchez-Ramos L, Duffy D. Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis. Am J Obstet Gynecol. 2011;204(6):558-556. pmid: 21752757 PubMed
Roos N, Kieler H, Sahlin L et al. Risk of adverse pregnancy outcomes in women with polycystic ovary syndrome: population based cohort study. BMJ. 2011 2011;343:d6309. pmid: 21998337 PubMed
Mathur R, Alexander CJ, Yano J, Trivax B, Azziz R. Use of metformin in polycystic ovary syndrome. Am J Obstet Gynecol. Dec 2008;199(6):596-609. PubMed
Hannaford PC, Selvaraj S, Elliott AM et al. Cancer risk among users of oral contraceptives: cohort data from the Royal College of General Practitioner's oral contraception study. BMJ. Sep 29 2007;335(7621):651. pmid: 17855280 PubMed
Bird ST, Hartzema AG, Brophy JM et al. Risk of venous thromboembolism in women with polycystic ovary syndrome: a population-based matched cohort analysis. CMAJ. Feb 5 2013;185(2):E115-120. pmid: 23209115 PubMed
Ravn P, Haugen AG, Glintborg D. Overweight in polycystic ovary syndrome. An update on evidence based advice on diet, exercise and metformin use for weight loss. Minerva Endocrinol. Mar 2013;38(1):59-76. PubMed
Legro RS, Arslanian SA, Ehrmann DA, et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. Dec 2013;98(12):4565-4592. PubMed
Al Khalifah RA, Florez ID, Dennis B, et al. Metformin or oral contraceptives for adolescents with polycystic ovarian syndrome: A meta-analysis. Pediatrics 2016; 137. pmid: 27244814 PubMed
Luque-Ramirez M, Escobar-Morreale HF. Treatment of polycystic ovary syndrome (PCOS) with metformin ameliorates insulin resistance in parallel with the decrease of serum interleukin-6 concentrations. Horm Metab Res. Oct 2010;42(11):815-820. PubMed
Sivalingam VN, Myers J, Nicholas Set al. Metformin in reproductive health, pregnancy and gynaecological cancer: established and emerging indications. Hum Reprod Update. Nov-Dec 2014;20(6):853-68. pmid: 25013215 PubMed
Frøssing S, Nylander M, Chabanova E, et al. Effect of liraglutide on ectopic fat in polycystic ovary syndrome: A randomized clinical trial. Diabetes Obes Metab 2017. pmid:28681988 PubMed
Ehrmann DA. Polycystic ovary syndrome. N Engl J Med. Mar 24 2005;352(12):1223-1236. pmid: 15788499 PubMed
Vassilatou E, Lafoyianni S, Vryonidou A, et al. Increased androgen bioavailability is associated with non-alcoholic fatty liver disease in women with polycystic ovary syndrome. Hum Reprod. Jan 2010;25(1):212-220. PubMed
Vgontzas AN, Legro RS, Bixler EO at al. Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance. J Clin Endocrinol Metab. Feb 2001;86(2):517-20. pmid: 11158002 PubMed
Manson MD. The tie that binds the dynamic duo: the connector between AS1 and AS2 in the HAMP domain of the Escherichia coli Tsr chemoreceptor. J Bacteriol. Oct 2008;190(20):6544-6547. PubMed
Hart R, Doherty DA. The potential implications of a PCOS diagnosis on a woman's long-term health using data linkage. Journal of Clinical Endocrinology and Metabolism 2015; 100(3): 911-19. PMID: 25532045 PubMed
Deeks AA,Gibson-Helm ME, Teede HJ. Anxiety and depression in polycystic ovary syndrome: a comprehensive investigation. Fertility and Sterility 2010; 93(7): 2421-23. PMID: 20117778 PubMed
Garelli S, Masiero S, Plebani M, et al. High prevalence of chronic thyroiditis in patients with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. Jul 2013;169(2):248-251. PubMed
Benetti-Pinto CL, Berini Piccolo VR, Garmes HM, Teatin Juliato CR. Subclinical hypothyroidism in young women with polycystic ovary syndrome: an analysis of clinical, hormonal, and metabolic parameters. Fertil Steril. Feb 2013;99(2):588-592. PubMed
Schmidt J, Landin-Wilhelmsen K, Brannstrom M, Dahlgren E. Cardiovascular disease and risk factors in PCOS women of postmenopausal age: a 21-year controlled follow-up study. J Clin Endocrinol Metab. Dec 2011;96(12):3794-3803. PubMed
Vanky E, Salvesen KA, Heimstad R, Fougner KJ, Romundstad P, Carlsen SM. Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study. Hum.Reprod. 2004;19(8):1734-40. pmid: 15178665 PubMed

Meld deg på nyhetsbrev

Er du helsepersonell?

Ved å oppgi dette kan du få bedre tilpasset innhold om du har formell helsefaglig kompetanse

Annonsørinnhold

Annonsørinnhold fra SOBI

Hvorfor blir penis bøyd?

Ingen penis er helt rett når den er erigert. Dette varierer fra mann til mann og vinkelen påvirker vanligvis ikke sexlivet, humøret eller selvtilliten. Ved Peyronies sykdom kan krumningen bli så stor at det kan by på problemer. Da finnes det hjelp å få.

Mest lest i dag

For helsepersonell

Polycystisk ovariesyndrom (PCOS)

Hopp til innhold

PregMet2-studien

Er du helsepersonell?

Annonsørinnhold

Hvorfor blir penis bøyd?

Mest lest i dag

Hvor mange skritt behøves?

Asperger syndrom

Vannkopper

Polycystisk ovariesyndrom (PCOS)

Hopp til innhold

PregMet2-studien

Er du helsepersonell?

Andre leste også dette

Kvinner med polycystisk ovariesyndrom utvikler lettere type 2-diabetes

QUIZ: PCOS

PCOS - trening hjelper også for slanke kvinner

Annonsørinnhold

Hvorfor blir penis bøyd?

Mest lest i dag

Hvor mange skritt behøves?

Asperger syndrom

Vannkopper