Informasjon

Ubehag i øvre del av magen, funksjonell dyspepsi

Funksjonell dyspepsi omtales av noen som magekatar, men det er en tilstand karakterisert ved tilbakevendende eller kroniske smerter og ubehag i øvre del av magen uten at man finner sykdomsforandringer i eller rundt fordøyelseskanalen.

Prognose

Plagene ved funksjonell dyspepsi kommer og går. De varierer i intensitet. Mange pasienter blir betydelig bedre når de blir kvitt den underliggende bekymringen for alvorlig sykdom. Men noen har vedvarende plager på tross av behandling og undersøkelser. Trøsten er at funksjonell dyspepsi er ufarlig, selv om det kan være plagsomt. Forskning har vist at selv pasienter med vedvarende funksjonell dyspepsi, ikke har økt risiko for kreft i magen.

Dette dokumentet er basert på det profesjonelle dokumentet "Funksjonell dyspepsi". Referanselisten for dette dokumentet vises nedenfor.

Loyd RA, McClellan DA. Update on the evaluation and management of functional dyspepsia. Am Fam Physician 2011; 83: 547-52. American Family Physician
Talley NJ, Ford AC. Functional Dyspepsia. N Engl J Med. 2015 Nov 5;373(19):1853-63. doi: 10.1056/NEJMra1501505 DOI
Tack J, Talley NJ, Camilleri M, et al. Functional gastroduodenal disorders. Gastroenterology 2006; 130:1466. Gastroenterology
Karamanolis G, Caenepeel P, Arts J, Tack J. Association of the predominant symptom with clinical characteristics and pathophysiological mechanisms in functional dyspepsia. Gastroenterology 2006; 130: 296-303. Gastroenterology
Talley NJ. American Gastroenterological Association medical position statement: evaluation of dyspepsia. Gastroenterology 2005; 129: 1753-5. Gastroenterology
Vanheel H, Carbone F, Valvekens L, et al. Pathophysiological abnormalities in functional dyspepsia subgroups according to the Rome III Criteria. Am J Gastroenterol 2017; 112:132. PubMed
Kaji M, Fujiwara Y, Shiba M, et al. Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life. J Gastroenterol Hepatol 2010; 25: 1151-6. PubMed
Dibaise JK, Islam RS, Dueck AC, et al. Psychological distress in Rome III functional dyspepsia patients presenting for testing of gastric emptying. Neurogastroenterol Motil 2016; 28:196–205.
Haug TT, Wilhelmsen I, Berstad A, Ursin H. Life-events and stress in patients with functional dyspepsia compared to patients with duodenal ulcer and healthy controls. Scand J Gastroenterol 1995; 6: 524-30. PubMed
Longstreth GF, Lacy BE. Functional dyspepsia in adults. UpToDate, last updated Nov 01, 2017. [url]https://www.uptodate.com/contents/functional-dyspepsia-in-adults? UpToDate
Wouters MM, Vicario M, Santos J. The role of mast cells in functional gastrointestinal disorders. Gut 2016; 65:155–168.
Sha W, Pasricha PJ, Chen JD. Correlations among electrogastrogram, gastric dysmotility, and duodenal dysmotility in patients with functional dyspepsia. J Clin Gastroenterol 2009; 43: 716-22. PubMed
Farré R, Vanheel H, Vanuytsel T, et al. In functional dyspepsia, hypersensitivity to postprandial distention correlates with meal-related symptom severity. Gastroenterology 2013; 145:566. Gastroenterology
Talley NJ, Walker MM, Holtmann G. Functional dyspepsia. Curr Opin Gastroenterol. 2016 Nov;32(6):467-473 . doi:10.1097/MOG.0000000000000306 DOI
Talley NJ, Hunt R. What role does Helicobacter pylori play in dyspepsia and nonulcer dyspepsia? Arguments for and against H. pylori being associated with dyspeptic symptoms. Gastroenterology 1997; 113(6 Suppl): S67-77.
Moayyedi P, Talley NJ, Fennerty MB, Vakil N. Can the clinical history distinguish between organic and functional dyspepsia. JAMA 2006; 295: 1566-76. Journal of the American Medical Association
Stanghellini V, Chan FK, Hasler WL, et al. Gastroduodenal disorders. Gastroenterology 2016; 150:1380–1392.
Laine L, Schoenfeld P, Fennerty B. Therapy for Helicobacter pylori in patients with nonulcer dyspepsia: a meta-analysis of randomized controlled trials. Ann Intern Med 2001; 134: 361-9. PubMed
Longstreth GF. Functional dyspepsia--managing the conundrum. N Engl J Med 2006; 354: 791-3 New England Journal of Medicine
Masuy I, Van Oudenhove L, Tack J. Review article: treatment options for functional dyspepsia. Aliment Pharmacol Ther. 2019 May;49(9):1134-1172. https://doi.org/10.1111/apt.15191.
Moayyedi P, Deeks J, Talley NJ, Delaney B, Forman D. An update of the Cochrane systematic review of Helicobacter pylori eradication therapy in nonulcer dyspepsia: resolving the discrepancy between systematic reviews. Am J Gastroenterol 2003;98: 2621-6. PubMed
Rabeneck L, Soucheck J, Wristers K, et al. A double-blind, randoized, placebo-controlled trial of proton pump inhibitor therapy in patients with univestigated dyspepsia. Am J Gastroenterol 2002; 97: 3045-51. PubMed
Moayyedi P, Delaney BC, Vakil N, Forman D, Talley NJ. The efficacy of proton pump inhibitors in nonulcer dyspepsia: a systematic review and economic analysis. Gastroenterology 2004; 127: 1329-37. Gastroenterology
Veldhuyzen van Zanten SJ, Chiba N, Armstrong D, et al. A randomized trial comparing omeprazole, ranitidine, cisapride, or placebo in Helicobacter pylori negative, primary care patients with dyspepsia: The CADET-HN study. Am J Gastroenterol 2005; 100: 1477-88. PubMed
Leung WK, Wu JC, Chan FK, et al. Initial treatment with lansoprazole in young dyspeptic patients with negative urea breath test result: a randomized controlled trial with 12-month follow-up. Am J Gastroenterol 2007; 102: 1483-8. PubMed
Statens Legemiddelverk (SLV). Nye anbefalinger ved bruk av metoklopramid. Juli 2013.
Melzer J, Rösch W, Reichling J, Brignoli R, Saller R. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Aliment Pharmacol Ther 2004; 20: 1279-87. PubMed
Jackson JL, O`Malley PG, Tomkins G, Balden E, Santoro J, Kroenke K. Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis. Am J Med 2000; 108:65-72. legehandboka.no
Zhao B, Zhao J, Cheng WF, et al. Efficacy of Helicobacter pylori eradication therapy on functional dyspepsia: a meta-analysis of randomized controlled studies with 12-month follow-up. J Clin Gastroenterol. 2014 ;48(3):241-7. doi: 10.1097/MCG.0b013e31829f2e25.
Mazzoleni LE, Sander GB, Francesconi CF, et al. Helicobacter pylori eradication in functional dyspepsia: HEROES trial. Arch Intern Med 2011; 171:1929. PubMed
Ford AC, Qume M, Moayyedi P, Arents NL, Lassen AT, Logan RF, et al. Helicobacter pylori "test and treat" or endoscopy for managing dyspepsia: an individual patient data meta-analysis. Gastroenterology 2005; 128: 1838-44. Gastroenterology
Lassen AT, Pedersen FM, Bytzer P, Schaffalitzky OB. Helicobacter pylori test-and eradicate versus prompt endoscopy for management of dyspeptic patients: a randomized trial. Lancet 2000; 356:455-60. PubMed
Mazzoleni LE, Sander GB, Francesconi CF, et al. Helicobacter pylori eradication in functional dyspepsia: HEROES trial. Arch Intern Med 2011; 171:1929. PubMed
Soo S, Forman D, Delaney BC, Moayyedi P. A systematic review of psychological therapies for nonulcer dyspepsia. Am J Gastroenterol 2004; 99: 1817-22. PubMed
Hamilton J, Guthrie E, Creed F, Thompson D, Tomenson B, Bennett R et al. A randomized controlled trial of psychotherapy in patients with chronic functional dyspepsia. Gastroenterology 2000; 119: 661-9. PubMed
Ford AC, Marwaha A, Sood R, Moayyedi P. Global prevalence of, and risk factors for, uninvestigated dyspepsia: a meta-analysis. Gut 2015; 64:1049. Gut

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