Hyperaldosteronisme
Hyperaldosteronisme er en tilstand der kroppen produserer for mye av hormonet aldosteron. Dette fører til høyt blodtrykk, og hos mange lavt kaliuminnhold i blodet.
Sist oppdatert:
5. jan. 2021
De to binyrene ligger ved den øvre enden av hver av de to nyrene, og de veier cirka sju gram hver. Binyrene består av to deler, binyremargen og binyrebarken. Binyremargen som utgjør de indre 20 prosent av kjertelen, er forbundet med det sympatiske nervesystemet og skiller ut hormonene adrenalin og noradrenalin - hormoner som mobiliserer kroppen til å mestre en akutt krise. Binyrebarken skiller ut en helt annen gruppe hormoner som kalles kortikosteroider eller adrenokortikale hormoner. Aldosteron tilhører denne gruppen hormoner.
Produksjonen av de adrenokortikale hormonene styres fra hjernen (hypothalamus og hypofysen) via hormonet ACTH. Ved behov for økt produksjon av adrenokortikale hormoner øker hjernen produksjonen av ACTH, som så stimulerer binyrene.
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Dette dokumentet er basert på det profesjonelle dokumentet Hyperaldosteronisme . Referanselisten for dette dokumentet vises nedenfor
- Grytaas MA, Bakke Å, Ueland GÅ, Jørgensen AP. Primær hyperaldosteronisme. Nasjonal veileder i endokrinologi. Versjon 3.1, publisert 18.09.2022. Siden lest 10.01.2024 https
- Funder JW, Carey RM, Mantero F, et al. The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2016; 101:1889. PubMed
- Charoensri S, Bashaw L, Dehmlow C, et al. Evaluation of a best-practice advisory for primary aldosteronism screening. JAMA Intern Med 2024. pmid:38190155 PubMed
- Brown JM, Siddiqui M, Calhoun DA, et al. The Unrecognized Prevalence of Primary Aldosteronism A Cross-sectional Study. Ann Intern Med 2020; 173: 10-20. pmid:32449886 PubMed
- Cohen DL, Wachtel H, Vaidya A, et al. Primary aldosteronism in chronic kidney disease: Blood pressure control and kidney and cardiovascular outcomes after surgical versus medical management. Hypertension 2023; 80: 2187. pmid:37593884 PubMed
- Buffolo F, Pecori A, Reincke M, et al. Long-term follow-up of patients with elevated aldosterone-to-renin ratio but negative confirmatory test: The progression of primary aldosteronism phenotypes. Hypertension 2024; 81: 340-347. pmid:38084587 PubMed
- Mulatero P, Stowasser M, Loh KC, et al. Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents. J Clin Endocrinol Metab 2004; 89: 1045. PubMed
- Stowasser M. Primary Aldosteronism: Rare bird or common cause of secondary hypertension?. Curr Hypertens Rep 2001; 3: 230. PubMed
- Hung A, Ahmed S, Gupta A, et al. Performance of the Aldosterone to Renin Ratio as a Screening Test for Primary Aldosteronism. J Clin Endocrinol Metab 2021; 106: 2423-35. pmid:34008000 PubMed
- Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999; 341: 709. New England Journal of Medicine
- Pitt B, Remme W, Zannad F, Neaton J. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003; 348: 1309. New England Journal of Medicine
- Williams TA, Lenders JWM, Mulatero P, et al. Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort. Lancet Diabetes Endocrinol 2017; 5: 689-99. pmid:28576687 PubMed
- Chen Y-Y, Lin Y-HH, Huang W-C, et al. Adrenalectomy Improves the Long-Term Risk of End-Stage Renal Disease and Mortality of Primary Aldosteronism. J Endocr Soc 2019; 3: 1110-26. pmid:31086833 PubMed
- Monticone S, D'Ascenzo F, Moretti C, et al. Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 2018; 6: 41-50. pmid:29129575 PubMed
- Hundemer GL, Agharazii M, Madore F, et al. Subclinical Primary Aldosteronism and Cardiovascular Health: A Population-Based Cohort Study. Circulation 2024; 149: 124-134. pmid:38031887 PubMed
- Stowasser M, Gordon RD, Gunasekera TG, et al. High rate of detection of primary aldosteronism, including surgically treatable forms, after 'non-selective' screening of hypertensive patients. J Hypertens. 2003; 21: 2149-57. 14597859
- Sechi LA, Novello M, Lapenna R, et al. Long-term renal outcomes in patients with primary aldosteronism. JAMA 2006; 295: 2638-45. PubMed