Hopp til innhold
NHI.no
Annonse

Perforasjon

Innhold i artikkelen

Et perforert magesår innebærer at fri luft kommer ut i bukhulen samt at innhold fra magesekk og/eller tolvfingertarm lekker ut i bukhulen. Galle, matrester, bakterier kan komme ut i bukhulen og forårsake en livstruende bukhinnebetennelse (peritonitt). Det kan også oppstå blodforgiftning (sepsis), blodtrykksfall og sjokk. Rask diagnose er avgjørende fordi prognosen er utmerket innenfor de første seks timene, men forringes og kan medføre død dersom den stilles mer enn 12 timer forsinket.

Annonse

Vil du vite mer

Dette dokumentet er basert på det profesjonelle dokumentet Magesår, komplikasjoner . Referanselisten for dette dokumentet vises nedenfor

  1. Vakil NB. Overview of the complications of peptic ulcer disease. UpToDate, last updated Oct 28, 2019 . www.uptodate.com
  2. Quan S, Frolkis A, Milne K, et al. Upper-gastrointestinal bleeding secondary to peptic ulcer disease: Incidence and outcomes. World J Gastroenterol. Dec 14, 2014; 20(46): 17568–17577. . doi:10.3748/wjg.v20.i46.17568 DOI
  3. Wang YR, Richter JE, Dempsey DT. Trends and outcomes of hospitalizations for peptic ulcer disease in the United States, 1993 to 2006. Ann Surg 2010; 251:51. PubMed
  4. Sadic J, Borgström A, Manjer J, et al. Bleeding peptic ulcer - time trends in incidence, treatment and mortality in Sweden. Aliment Pharmacol Ther 2009; 30:392. PubMed
  5. Bashinskaya B, Nahed BV, Redjal N, et al. Trends in Peptic Ulcer Disease and the Identification of Helicobacter Pylori as a Causative Organism: Population-based Estimates from the US Nationwide Inpatient Sample. J Glob Infect Dis 2011; 3:366. PubMed
  6. Vestergård A, Bredahl K, Schaffalitzky de Muckadell OB, Pedersen OB, Møller Hansen J. Blødende peptisk ulcus. Ugeskr Læger 2009; 171: 235. Ugeskrift for Læger
  7. Sung JJ, Tsoi KK, Ma TK, Yung MY, Lau JY, Chiu PW, Causes of mortality in patients with peptic ulcer bleeding: a prospective cohort study of 10,428 cases. Am J Gastroenterol 2010;105: 84-9. PubMed
  8. Chiu PW, Ng EK, Cheung FK, et al, Predicting mortality in patients with bleeding peptic ulcers after therapeutic endoscopy. Clin Gastroenterol Hepatol 2009;7: 311-6. doi:10.1016/j.cgh.2008.08.044 DOI
  9. Lau JY, Sung J, Hill C, Henderson C, Howden CW, Metz DC. Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality. Digestion 2011;84: 102-13. PubMed
  10. Laine L. Clinical practice. Upper Gastrointestinal Bleeding Due to a Peptic Ulcer. N Engl J Med 2016; 374:2367. PubMed
  11. Wang CH, Ma MH, Chou HC, et al. High-dose vs non-high-dose proton pump inhibitors after endoscopic treatment in patients with bleeding peptic ulcer: a systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 2010; 170: 751-8. PubMed
  12. Neumann I, Letelier LM, Rada G, et al. Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding. Cochrane Database Syst Rev 2013 Jun 12;6:CD007999. Cochrane (DOI)
  13. Bisgaard T, Bojer D, Schulze S, Gerlach Øgard C. Mavesår, komplikationer. Lægehåndbogen. Sist faglig oppdatert 08.10.2021.
  14. Barkun AN, Bardou M, Kuipers AJ, et al. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med 2010; 152: 101-13. Annals of Internal Medicine
  15. Thorsen K, Søreide JA, Søreide K, Long-Term Mortality in Patients Operated for Perforated Peptic Ulcer: Factors Limiting Longevity are Dominated by Older Age, Comorbidity Burden and Severe Postoperative Complications.. World J Surg 2017;41: 410-418. PubMed
  16. Aziz F. Surgical treatment of perforated peptic ulcer. Medscape, last updated Apr 27, 2016. emedicine.medscape.com
Annonse
Annonse