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Aortastenose, forsnevring i aortaklaffen: Årsaker

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En forsnevring av aortaklaffen som oppdages før 50 års alder skyldes som regel en medfødt 2-bladet aortaklaff (normalt er den 3-bladet). I aldersgruppen 50-70 år er fortsatt en stor andel forårsaket av 2-bladet klaff, men de som får sykdommen etter fylte 70 år har som regel en normal 3-bladet klaff. De får sykdommen på grunn av alders- og belastningsforandringer i klaffen. Giktfeber (betennelser i ledd og hjerte etter streptokokk halsbetennelse) var tidligere en vanlig årsak, men dette er nå svært sjelden.

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Dette dokumentet er basert på det profesjonelle dokumentet Aortastenose . Referanselisten for dette dokumentet vises nedenfor

  1. Joseph J, Naqvi SY, Giri J, Goldberg S. Aortic Stenosis: Pathophysiology, Diagnosis, and Therapy. Am J Med. 2017;130(3):253-263. PMID: 27810479. PubMed
  2. Bøe E. Asymptomatisk høygradig aortastenose - avvente eller igangsette behandling? Hjerteforum 2023; 36: 16-25. www.legeforeningen.no
  3. Nkomo VT, Gardin JM, Skelton TM, et al. Burden of valvular heart diseases: a population-based study. Lancet 2006; 368: 1005-11. PubMed
  4. Eveborn GW, Schirmer H, Heggelund G, et al. The evolving epidemiology of valvular aortic stenosis. the Tromsø study. Heart 2013; 99:396. PubMed
  5. Yadgir S, Johnson CO, Aboyans V, et al. Global Burden of Disease Study Nonrheumatic Valve Disease Collaborators. Global, regional, and national burden of calcific aortic valve and degenerative mitral valve diseases, 1990-2017 . Circulation 2020; 141: 1670-80. pmid:32223336 PubMed
  6. Lewin MB, Otto CM. The bicuspid aortic valve: adverse outcomes from infancy to old age. Circulation. 2005;111(7):832–834.
  7. Kaiser Y, Nurmohamed NS, Kroon J. Lipoprotein(a) has no major impact on calcification activity in patients with mild to moderate aortic valve stenosis. Heart 2022. doi:10.1136/heartjnl-2021-319804 DOI
  8. Chan K-L. Lipoprotein(a) and aortic stenosis. Editorial. Heart 2021. doi:10.1136/heartjnl-2021-320173 DOI
  9. Kronenberg F, Mora S, Stroes ESG, et al. Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement. Eur Heart J 2022. doi:10.1093/eurheartj/ehac361 DOI
  10. Farina JM, Chao C-J, Pereyra M, et al . Role of lipoprotein(a) concentrations in bioprosthetic aortic valve degeneration. Heart 2024; 110: 299-305. pmid:37643771 PubMed
  11. Gaasch WH. Natural history, epidemiology, and prognosis of aortic stenosis. UpToDate, last updated Apr 13, 2020. UpToDate
  12. Grimard BH, Safford RE, Burns EL. Aortic stenosis: diagnosis and treatment. Am Fam Physician. 2016 Mar 1;93(5):371-378.
  13. Otto CM. Clinical features and evaluation of aortic stenosis in adults. UpToDate 2013.
  14. Kassis N, Hariri EH, Karrthik AK, et al. Supplemental calcium and vitamin D and long-term mortality in aortic stenosis. Heart 2022; 108: 964-72. pmid:35470234 PubMed
  15. Lau FD, Giugliano RP. Lipoprotein(a) and its Significance in Cardiovascular Disease A Review. JAMA Cardiol 2022. doi:10.1001/jamacardio.2022.0987 DOI
  16. Frey N, Steeds RP, Rudolph TK, et al. Symptoms, disease severity and treatment of adults with a new diagnosis of severe aortic stenosis. Heart 2019; 105: 1709-16. pmid:31302639 PubMed
  17. Chambers J. Aortic stenosis. BMJ 2005; 330: 801-2. PubMed
  18. Vahanian A, Beyersdorf F, Praz F, et al. 2021 ESC/EACTS Guidelines for the management of valvular heart disease: Developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 2021. doi:10.1093/eurheartj/ehab395 DOI
  19. Thomassen HK, Cioffi G, Gerdts E, et al. Echocardiographic aortic valve calcification and outcomes in women and men with aortic stenosis . Heart 2017. doi:10.1136/heartjnl-2016-311040 DOI
  20. Nishimura RA, Otto CM, Bonow RO, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63(22):2438–2488.
  21. Nguyen V, Estellat C, Codogno I, et al . Haemodynamic and anatomic progression of aortic stenosis. Heart 2015. doi:10.1136/heartjnl-2014-307154 DOI
  22. Wang TY, Svensson LG, Wen J, et al. Apixaban or Warfarin in Patients with an On-X Mechanical Aortic Valve. NEJM Evidence 2023. doi:10.1056/EVIDoa2300067 DOI
  23. Bejjani A, Khairani CD, Assi A, et al. When Direct Oral Anticoagulants Should Not Be Standard Treatment: JACC State-of-the-Art Review. J Am Coll Cardiol 2024; 83: 444-465. pmid:38233019 PubMed
  24. Chan KL, Teo K, Dumesnil JG, et al. Effect of lipid lowering with rosuvastatin on pregression of aortic stenosis. Results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial. Circulation 2010; : PMID: 20048204. PubMed
  25. El-Hamamsy I, Eryigit Z, Stevens L-M, et al. Long term outcomes after autograft versus homograft aortic root replacement in adults with aortic valve disease: a randomisedm controlled trial. Lancet 2010; 376: 524-31. PubMed
  26. Steigen TK, Schive B, Næsheim T, Busund R. Transkateter aortaventilimplantasjon ved aortastenose. Tidsskr Nor Legeforen 2011; 131: 343-8. Tidsskrift for Den norske legeforening
  27. Kodali SK, Williams MR, Smith CR, et al. Two-year outcomes after transcatheter or surgical aortic-valve replacement. N Engl J Med 2012; 366: 1686-95. New England Journal of Medicine
  28. Woldendorp K, Indja B, Bannon PG, et al. Silent brain infarcts and early cognitive outcomes after transcatheter aortic valve implantation: a systematic review and meta-analysis. Eur Heart J 2021. pmid:33517376 PubMed
  29. Mack MJ, Leon MB, Thourani VH, et al. Transcatheter aortic-valve replacement in low-risk patients at five years. N Engl J Med 2023; 389:1949. PMID: 37874020 PubMed
  30. Mack MJ, Brennan JM, Brindis R, et al. Outcomes following transcatheter aortic valve replacement in the United States. JAMA 2013; 310: 2069-77. doi:10.1001/jama.2013.282043 DOI
  31. Leon MB, Smith CR, Mack MJ, et al. for the PARTNER 2 Investigators. Transcatheter or surgical aortic-valve replacement in intermediate-risk patients. N Engl J Med 2016. doi: 10.1056/NEJMoa1514616 DOI
  32. Van Mieghem NM, Deeb GM, Søndergaard L, et al. Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients: 5-Year Outcomes of the SURTAVI Randomized Clinical Trial. JAMA Cardiol 2022; 7: 1000-1008. pmid:36001335 PubMed
  33. Zahn R, Werner N, Gerckens U, et al. Five-year follow-up after transcatheter aortic valve implantation for symptomatic aortic stenosis . Heart 2017. doi:10.1136/heartjnl-2016-311004 DOI
  34. Rossebø AB, Pedersen TR, Boman K, et al. Intensive lipid-lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med 2008; 359: 1343-56. PubMed
  35. Otto CM, Newby DE, Hillis GS. Calcific Aortic Stenosis. A Review. JAMA 2024. doi:10.1001/jama.2024.16477 DOI
  36. Varadarajan P, Kapoor N, Bansal RC, et al. Clinical profile and natural history of 453 nonsurgically managed patients wiith severe aortic stenosis. Ann Thorac Surg 2006; 82: 2111-5. PubMed
  37. Head SJ, Gahl B, Celik M, et al. Natural history of asymptomatic severe aortic stenosis and the association of early Intervention with outcomes: A systematic review and meta-analysis. JAMA Cardiol 2020; 5: 1102-1112. pmid:32639521 PubMed
  38. Lancelotti P. Magne J, Dulgheru R, et al. Outcomes of patients with asymptomatic aortic stenosis followed up in heart valve clinics. JAMA Cardiol 2018; 3: 1060-1068. pmid:30285058 PubMed
  39. Sharabiani MTA, Fiorentino F, Angelini GD, Patel NN. Long-term survival after surgical aortic valve replacement among patients over 65 years of age. Open Heart 2016. doi:10.1136/openhrt-2015-000338 DOI
  40. Hibino M, Pandey AK, Hibino H, et al. Mortality trends of aortic stenosis in high-income countries from 2000 to 2020. Heart 2023. doi:10.1136/heartjnl-2023-322397 DOI
  41. Tzemos N, Therrien J, Yip J, et al. Outcomes in adults with bicuspid aortic valves. JAMA 2008; 300: 1317-25. Journal of the American Medical Association
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