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Hypersensitivitet til gluten uten å ha cøliaki?: Systematisk oversikt

I denne metaanalysen fra april 2015 fant forskerne 17 studier av NCGS3. Prevalens varierte betydelig fra 0,5% til 13%. HLADQ2/DQ8 haplotyper var tilstede hos 44% av NCGS-pasientene, og forskerne antyder at en andel av pasientene kan ha såkalt "cøliaki-lett". Den gunstige effekten av glutenfri kost blant NCGS-pasienter er kontroversiell, men det angis at HLADQ2-postive pasienter med diare-type irritabel tarm kan ha nytte av glutenfri kost.

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  1. Balistreri WF. Could This Patient Have 'Non-Celiac Gluten Sensitivity'?. Medscape Feb 11, 2013. www.medscape.com
  2. O'Brien K. Should we all go gluten-free? The New York Times. November 25, 2012. http://www.nytimes.com/2011/11/27/magazine/Should-We-All-Go-Gluten-Free.html?pagewanted=all&_r=0. Accessed January 25, 2013.
  3. Molina-Infante J, Santolaria S, Sanders DS, Fernández-Bañares F. Noncoeliac gluten sensitivity: A systematic review. Aliment. Pharmacol. Ther. 2015 Mar 06 . doi:10.1111/apt.13155 DOI
  4. Biesiekierski JR, Newnham ED, Irving PM, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol 2011; 106: 508-514.
  5. Biesiekierski JR, Peters SL, Newnham ED, Rosella O, Muir JG, Gibson PR. "No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates." Gastroenterology. 2013 Aug;145(2):320-8.e1-3.
  6. Biesiekierski JR, Muir JG, Gibson PR. "Is gluten a cause of gastrointestinal symptoms in people without celiac disease?" Curr Allergy Asthma Rep. 2013 Dec;13(6):631-8.
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