Informasjon

Diabetes type 1

Forekomst

Cirka 28.000 mennesker har diabetes type 1 i Norge. Diabetes type 1 kan debutere i alle aldre, men over halvparten får denne diagnosen før de fyller 18 år. Omkring 300 nye personer under 15 års alder får diabetes type 1 hvert år i Norge. I 2020 fikk rekordmange barn og ungdommer i Norge diagnosen diabetes type 1, totalt 467 personer. Sykdomsforekomsten av diabetes type 1 er blitt doblet fra 1960-1980, men den ser ut til å flate ut nå i nyere tid. Det er geografiske forskjeller i hyppigheten av diabetes type 1. Lavest antall nye tilfeller finner vi i Finnmark, høyest i Agder.

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Dette dokumentet er basert på det profesjonelle dokumentet "Diabetes type 1". Referanselisten for dette dokumentet vises nedenfor.

Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet. 2014 Jan 4; 383(9911): 69–82. www.ncbi.nlm.nih.gov
Helsedirektoratet. Nasjonal faglig retningslinje for diabetes. Sist oppdatert 15.04.2020. helsedirektoratet.no
Atkinson MA, Roep BO, Posgai A, Wheeler DCS, Peakman M. The challenge of modulating β-cell autoimmunity in type 1 diabetes. Lancet Diabetes Endocrinol. 2019;7(1):52-64. PMID: 30528099. PubMed
Kakleas K, Karayianni C, Critselis E, et al. The prevalence and risk factors for coeliac disease among children and adolescents with type 1 diabetes mellitus. Diabetes Res Clin Pract 2010;90:202-208. PubMed
Davis AK, DuBose SN, Haller MJ, et al. Prevalence of detectable C-peptide according to age at diagnosis and duration of type 1 diabetes. Diabetes Care December 17, 2014. Published online before print December 17, 2014, . doi:10.2337/dc14-1952 DOI
Wang L, Lovejoy NF, Faustman DL. Persistence of prolonged C-peptide production in type 1 diabetes as measured with an ultrasensitive C-peptide assay. Diabetes Care 2012; 35: 465-70. pmid:22355018 PubMed
Atkinson MA, Eisenbarth GS. Type 1A diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001;358: 221-9. PubMed
Harjutsalo V, Podar T, Tuomilehto J. Cumulative incidence of type 1 diabetes in 10,168 siblings of Finnish young-onset type 1 diabetic patients. Diabetes 2005; 54: 563-69. PubMed
Norris JM, Beaty B, Klingensmith G, Yu L, Hoffman M, Chase HP, et al. Lack of association between early exposure to cow's milk protein and -cell autoimmunity: diabetes autoimmunity study in the young (DAISY). JAMA 1996;276: 609-14. Journal of the American Medical Association
Hober D, Sauter P. Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host. Nat Rev Endocrinol 2010;6:279-289 PubMed
Norris JM, Barriga K, Klingensmith G, Hoffman M, Eisenbarth GS, Erlich HA, et al. Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA 2003;290: 1713-20. Journal of the American Medical Association
Ziegler AG, Schmid S, Huber D, Hummel M, Bonifacio E. Early infant feeding and risk of developing type 1A diabetes-associated autoantibodies. JAMA 2003;290: 1721-8. Journal of the American Medical Association
Lombardi A, Tsomos E, Hammerstad SS, Tomer Y. Interferon alpha: The key trigger of type 1 diabetes. J Autoimmun. 2018;94:7-15. PMID: 30115527. PubMed
Fousteri G, Dave Jhatakia A. Viral Infections and Autoimmune Disease: Roles of LCMV in Delineating Mechanisms of Immune Tolerance. Viruses. 2019;11(10):885. Published 2019 Sep 21. PMID: 31546586. PubMed
Usher-Smith JA, Thompson MJ, Sharp SJ, Walter FM. Factors associated with the presence of diabetic ketoacidosis at diagnosis of diabetes in children and young adults; a systematic review. BMJ 2011; 343: d4092. BMJ (DOI)
Crawford F, Cezard G, Chappell FM, et al. A systematic review and individual patient data meta-analysis of prognostic factors for foot ulceration in people with diabetes: the international research collaboration for the prediction of diabetic foot ulcerations (PODUS). Health Technol Assess. 2015 Jul;19(57):1-210. PubMed
Hals IK, Fiskvik Fleiner H, Reimers N, et al. Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial.. Diabetes Obes Metab 2019; 21: 2219-27. pmid:31148332 PubMed
Lind M et al. HbA1c level as a risk factor for retinopathy and nephropathy in children and adults with type 1 diabetes: Swedish population based cohort study. BMJ 2019 Aug 28; 366:l4894. pmid: 31462492 PubMed
Birkeland KI. Insulinbehandling ved type 1-diabetes hos voksne. Tidsskr Nor Legeforen 2006; 126: 776-8. PubMed
Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study. JAMA 2003; 290: 2159-67. Journal of the American Medical Association
Boyko EJ, Zelnick LR, Braffet B, et al. Risk of Foot Ulcer and Lower-Extremity Amputation Among Participants in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study. Diabetes Care 2022; 45: 357-364. pmid:35007329 PubMed
Nathan DM, Cleary PA, Backlund JY, et al, for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with Type 1 diabetes. N Engl J Med 2005; 353: 2643-53. New England Journal of Medicine
Musso G, Sircana A, Saba F, et al. Assessing the risk of ketoacidosis due to sodium-glucose cotransporter (SGLT)-2 inhibitors in patients with type 1 diabetes: A meta-analysis and meta-regression. PLoS Med. 2020 Dec 29;17(12):e1003461. PMID: 33373368 PubMed
Mahase E. Type 1 diabetes drug was withdrawn because of a “commercial conflict of interest,” charity argues. BMJ News 2022; 376:o373. Published 14 February 2022. doi:10.1136/bmj.o373 DOI
Avgerinos I, Manolopoulos A, Michailidis T, et al. Comparative efficacy and safety of glucose-lowering drugs as adjunctive therapy for adults with type 1 diabetes: A systematic review and network meta-analysis. Diabetes Obes Metab. 2020. PMID: 33300282 PubMed
Thalange N, Bereket A, Larsen J, et al. Insulin analogues in children with Type 1 diabetes: a 52-week randomized clinical trial. Diabet Med 2013 Feb; 30(2): 216-25. PubMed
Lane W, Bailey TS, Gerety G, et al. Effect of Insulin Degludec vs Insulin Glargine U100 on Hypoglycemia in Patients With Type 1 Diabetes The SWITCH 1 Randomized Clinical Trial. JAMA 2017; 318: 33-44. doi:10.1001/jama.2017.7115 DOI
Davies MJ, Gross JL, Ono Y, et al. Efficacy and safety of insulin degludec given as part of basal-bolus treatment with mealtime insulin aspart in type 1 diabetes: a 26-week randomized, open-label, treat-to-target non-inferiority trial. Diabetes Obes Metab. 2014 Apr 7.
Nørgaard K, Sohlberg A, Goodall G. Omkostningseffektivitet ved behandling af type 1-diabetes med insulinpumpe. Ugeskr Læger 2010; 172: 2020. Ugeskrift for Læger
Bergenstal RM, Tamborlane WV, Ahmann A, et al. Effectiveness of Sensor-augmented insulin-pump therapy in type 1 diabetes. N Engl J Med, June 29, 2010.
Russell SJ, El-Khatib FH, Sinha M, et al. Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes. N Engl J Med 2014. doi:DOI: 10.1056/NEJMoa1314474 DOI
Brown SA, Kovatchev BP, Raghinaru D, et al. Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes. N Engl J Med 2019; 381: 1707-17. pmid:31618560 PubMed
Burnside MJ, Lewis DM, Crocket HR, et al. Open-Source Automated Insulin Delivery in Type 1 Diabetes. N Engl J Med 2022; 387: 869-881. pmid:36069869 PubMed
Hussain MA, Theise ND. Stem-cell therapy for diabetes mellitus. Lancet 2004; 364: 203-5. PubMed
Writing Committee for the Type 1 Diabetes TrialNet Oral Insulin Study Group . Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes A Randomized Clinical Trial. JAMA 2017; 318: 1891-902. pmid:29164254 PubMed
The Diabetes Virus Detection and Intervention Trial. Nettside besøkt 06.12.20. forskningsprosjekter.ihelse.net
Gagnum V, Saeed M, Stene LC, et al. Low Incidence of End-Stage Renal Disease in Childhood-Onset Type 1 Diabetes Followed for Up to 42 Years.. Diabetes Care 2018; 41: 420-5. pmid:29025877 PubMed
Toni G, Berioli MG, Cerquiglini L, et al. Eating Disorders and Disordered Eating Symptoms in Adolescents with Type 1 Diabetes. Nutrients. 2017;9(8):906. Published 2017 Aug 19. PMID: 28825608. PubMed
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group, Nathan DM, Zinman B, et al. Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005). Arch Intern Med 2009; 169:1307. PubMed
Finne P, Reunanen A, Stenman S, Groop P-H, Grönhagen-Riska C. Incidence of end-stage renal disease in patients with type 1 diabetes. JAMA 2005; 294: 1782-7. PubMed
Holte KB, Svanteson M, Hanssen KF, Haig Y, Solheim S, Berg TJ. Undiagnosed coronary artery disease in long-term type 1 diabetes. The Dialong study. J Diabetes Complications. 2019;33(5):383-389. PMID: 30846232 PubMed
Lind M, Bounias I, Olsson M, et al. Glycaemic control and incidence of heart failure in 20985 patients with type 1 diabetes: an observational study. Lancet 2011; 378: 140-6. PubMed
Lind M, Svensson A-M, Kosiborod M, et al. Glycemic Control and Excess Mortality in Type 1 Diabetes. N Engl J Med 2014; 371: 1972-82. doi:10.1056/NEJMoa1408214 DOI
Matuleviciene-Anängen V, Rosengren A, Svensson AM, et al. Glycaemic control and excess risk of major coronary events in persons with type 1 diabetes. Heart 2017. pmid:28710186 PubMed
Huxley RR, Peters SA, Mishra GD, Woodward M. Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2015;3:198-206. doi:10.1016/S2213-8587(14)70248-7 DOI
Edwards J, Stapley S. Debridement of diabetic foot ulcers. Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD003556. DOI: 10.1002/14651858.CD003556.pub2. DOI
Larkin ME, Barnie A, Braffett BH, et al. Musculoskeletal Complications in Type 1 Diabetes. Diabetes Care. 2014 Apr 10.
Juel NG, Brox JI, Brunborg C, et al. Very High Prevalence of Frozen Shoulder in Patients With Type 1 Diabetes of ≥45 Years' Duration: The Dialong Shoulder Study. Arch Phys Med Rehabil 2017; 98: 1551-9. pmid:28219686 PubMed
Perkins BA, Ficociello LH, Silva KH. Regression of microalbuminuria in type 1 diabetes. N Engl J Med 2003; 348: 2285-93. pmid:12788992 PubMed
Cooper MN, de Klerk NH, Jones TW, Davis EA.. Clinical and demographic risk factors associated with mortality during early adulthood in a population-based cohort of childhood-onset type 1 diabetes. Diabet Med 2014; 31(12): 1550-8. doi:10.1111/dme.12522 DOI
Katz M, Laffel L. Mortality in type 1 diabetes in the current era. Two steps forward, one step backward. JAMA. 2015;313(1):35-36 . doi:10.1001/jama.2014.16327 DOI
Orchard TJ, Secrest AM, Miller RG, Costacou T. In the absence of renal disease, 20 year mortality risk in type 1 diabetes is comparable to that of the general population. Diabetologia. 2010;53(11):2312-2319. PubMed
Groop PH, Thomas MC, Moran JL, et al; FinnDiane Study Group. The presence and severity of chronic kidney disease predicts all-cause mortality in type 1 diabetes. Diabetes. 2009;58(7):1651-1658. PubMed
Hallström S, Wijkman MO, Ludvigsson J, et al. Risk factors, mortality trends and cardiovasuclar diseases in people with Type 1 diabetes and controls: A Swedish observational cohort study. Lancet Reg Health Eur. 2022;21:100469. Published 2022 Jul 22. doi:10.1016/j.lanepe.2022.100469. PMID: 35898332 PubMed
DCCT/EDIC Research Group. Association between 7 years of intensive treatment of type 1 diabetes and long-term mortality. JAMA. doi:10.1001/jama.2014.16107. DOI
Havas S, Donner T. Tight control of type 1 diabetes: Recommendations for patients. Am Fam Physician 2006; 74: 971-8. PubMed
Livingstone SJ, Levin D, Looker HC, et al. Estimated life expectancy in a Scottish cohort with type 1 diabetes, 2008-2010. JAMA. 2015;313(1):37-44. . doi:10.1001/jama.2014.16425 DOI
Krogvold L, Edwin B, Buanes T, et al. Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes 2015; 64: 1682-7. pmid:25422108 PubMed
Abbasi J. Type 1 Diabetes Advances Could Pave Way for Prevention. Medical News & Perspectives. August 2019
Julsrud Berg T. Diabetes mellitus. Norsk legemiddelhåndbok, sist endret 19.09.2018. www.legemiddelhandboka.no

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